Table 5.
Multivariable proportional hazards models of time to all deaths, AIDS deaths and non-AIDS deaths within 3 years versus greater than 3 years by VACS Index, FFI, CES-D and age among HIV+ women who were ART-experienced.
| Variable | A. All deaths within 3 years after FFI visit | B. All deaths later than 3 years after FFI visit | ||||
| χ2 | Multivariate-adjusted HR* (95% CI) | p Value | χ2 | Multivariate-adjusted HR* (95% CI) | p Value | |
| VACS Index per 20 points | 69.04 | 2.20 (1.83 to 2.65) | <0.0001 | 23.88 | 1.55 (1.30 to 1.84) | <0.0001 |
| FFI (3–5 vs 0–2 points) | 6.73 | 2.06 (1.19 to 3.57) | 0.01 | 16.18 | 2.43 (1.58 to 3.75) | 0.0001 |
| CES-D (<16 vs ≥16 points) | 1.01 | 1.32 (0.77 to 2.28) | 0.31 | 0.11 | 1.07 (0.71 to 1.62) | 0.74 |
| Age per decade | 0.09 | 1.05 (0.77 to 1.42) | 0.76 | 3.24 | 1.26 (0.98 to 1.61) | 0.07 |
| C. AIDS deaths within 3 years or less after FFI visit | D. AIDS deaths later than 3 years after FFI visit | |||||
| χ2 | Multivariate-adjusted HR* (95% CI) | p Value | χ2 | Multivariate-adjusted HR* (95% CI) | p Value | |
| VACS Index per 20 points | 80.32 | 3.33 (2.56, 4.33) | 0.0000 | 13.97 | 1.75 (1.31 to 2.35) | 0.0002 |
| FFI (3–5 vs 0–2 points) | 0.88 | 1.45 (0.67, 3.14) | 0.34 | 9.40 | 3.38 (1.55 to 7.37) | 0.002 |
| CES-D (<16 vs ≥16 points) | 1.96 | 1.73 (0.80, 3.73) | 0.17 | 0.81 | 1.43 (0.65 to 3.14) | 0.37 |
| Age per decade | 2.42 | 0.72 (0.47, 1.09) | 0.12 | 0.09 | 0.93 (0.58 to 1.50) | 0.77 |
| E. Non-AIDS deaths within 3 years or less after FFI visit | F. Non-AIDS deaths later than 3 years after FFI visit | |||||
| χ2 | Multivariate-adjusted HR* (95% CI) | p Value | χ2 | Multivariate-adjusted HR* (95% CI) | p Value | |
| VACS Index per 20 points | 0.80 | 1.16 (0.83 to 1.62) | 0.37 | 5.84 | 1.41 (1.07 to 1.86) | 0.016 |
| FFI (3–5 vs 0–2 points) | 9.15 | 3.37 (1.53 to 7.40) | 0.003 | 11.95 | 3.20 (1.66 to 6.20) | 0.0005 |
| CES-D (<16 vs ≥16 points) | 0.15 | 1.17 (0.54 to 2.54) | 0.70 | 0.60 | 0.77 (0.40 to 1.48) | 0.44 |
| Age per decade | 7.43 | 1.90 (1.20 to 3.02) | 0.006 | 1.44 | 1.26 (0.86 to 1.84) | 0.23 |
*Multivariate models included race/ethnicity; education less than or equal to versus greater than high school; smoking current versus no; income less than versus greater than or equal to $12 000 annually; alcohol use: low, moderate or high versus none; and body mass index <30 vs >30 kg/m2.
ART, antiretroviral therapies; CES-D, Center for Epidemiologic Studies-Depression; FFI, Fried Frailty Index; HIV+, HIV-infected; VACS, Veterans Aging Cohort Study.