Table 4.

False-negative and false-positive diagnosis of different assessment strategies

Strategy	False positives, %			False negatives, %
	Mean	(95% CI)	p Value	Mean	(95% CI)	p Value
(1) Standard	6.6	(6.4 to 6.9)		3.4	(3.2 to 3.6)
(2) hsTnI	7.0	(6.7 to 7.2)	0.06*	3.0	(2.8 to 3.2)	0.002*
(3) hsTnI+LoD	6.5	(6.3 to 6.8)	0.62*; 0.02†	3.0	(2.8 to 3.2)	0.002*; 1.00†
(4) hsTnI+ ADP	3.4	(3.2 to 3.5)	<0.001*,†	3.0	(2.9 to 3.2)	0.005*; 0.84†
(5) hsTnI+LoD+ADP	3.3	(3.1 to 3.4)	<0.001*,†	3.0	(2.9 to 3.2)	0.005*; 0.84†
(6) hsTnI+LoD+ADP+direct rule-in	3.3	(3.1 to 3.4)	<0.001*,†	2.8	(2.6 to 2.9)	<0.001*; 0.05†

False positives: Number of patients diagnosed with ACS and a 30 days adjudicated diagnosis of non-ACS.

False negatives: Number of patients not diagnosed with ACS and a 30 days adjudicated diagnosis of ACS.

*p Value versus strategy 1 (standard care)

†p Value versus strategy 2 (hsTnI)

ACS, acute coronary syndrome; ADP, modified ADAPT accelerated diagnostic protocol; hsTnI, high-sensitivity troponin I; LoD, limit of detection.