Table 1.
The pattern of Epstein Barr virus (EBV) latent gene expression and promoter usage.
| Type of Latency | Latent Gene Expression | Promoter Hypermethylation | EBV-Associated Diseases | ||
|---|---|---|---|---|---|
| Cp/Wp | Qp | LMP1p | |||
| Type I | EBNA1 | + | − | + | Burkitt lymphoma; Gastric cancer |
| Type II | EBNA1, LMP1, LMP2 | + | − | +/− | Nasopharyngeal cancer, Hodgikin disease, NK/T cell lymphoma |
| Type III | EBNA1–6, LMP1, LMP2 | − | − | − | Immunosuppressive lymphoma |
EBV, Epstein-Barr virus; EBNA, Epstein-Barr Virus nuclear antigen; LMP1, Latent membrane protein 1; Cp, C promoter; Wp, W promoter.