Table 2.

Summary of FHL Incidence. Listed are each FHL subtype, the percentage of particular subtypes in respect to all FHL cases, the etiological gene, and the gene size. Amount of mutations in coding region of gene was calculated using mutations found in Leiden Open Variation Dataase, NCBI SNP database, and primary literature.

FHL Type	Percentage of FHL Types for All FHL Cases	Gene	Protein Size (Amino Acids)	Number of Mutations in Coding Region of Gene	Mutation Rate (per 100 Amino Accids)
FHL 1	4 cases total	Unknown	Unknown	Unknown	Unknown
FHL 2	20–40% (>50% in African American families)	PRF1	555	133	23.9
FHL 3	20–30%	UNC13D	1090	38	3.5
FHL 4	20% in Turkish families	STX11	287	8	2.7
FHL 5	15–20%	STXBP2	593	18	3.0