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. 2017 Jul 25;18(8):1616. doi: 10.3390/ijms18081616

Figure 5.

Figure 5

Schematic representation the anti-cancerogenic roles of Tan-IIA. CCL2: Chemokine (C-C motif) ligand 2; EMT: Epithelial-Mesenchymal Transition; HIF-1α: Hypoxia-inducible factor-1α; MMP: Matrix MetalloProteinases; mTOR: mammalian target of rapamycin; P: phosphorylation; p70S6K: p70 ribosomal protein S6 kinase; STAT3: signal transducer and activator of transcription 3; Tan-IIA: Tanshinone IIA; TGF-β: transforming growth factor β. ↓: stimulatory modification; ⊥: inhibitory modification; Dashed arrow: putative stimulatory modification [47,48,49,50].