Table 2.
Clinical outcomes of all patients according to age, treatment, and RUNX1 mutation status.
| Response | Younger Cohort (Chemotherapy) | Elderly Cohort (HMA) | ||||
|---|---|---|---|---|---|---|
| n (%) | n (%) | |||||
| RUNX1WT | RUNX1mut | p-Value | RUNX1WT | RUNX1mut | p-Value | |
| (n = 168) | (n = 9) | (n = 127) | (n = 24) | |||
| Complete remission | 128 (76.2) | 3 (33.3) | 0.004 * | 48 (37.8) | 9 (37.5) | 0.976 |
| Complete remission with incomplete platelet recovery | 9 (5.4) | 3 (33.3) | 0.271 | 11 (8.7) | 1 (4.2) | 0.667 |
| Hematological improvement | 4 (2.4) | 1 (11.1) | 0.631 | 17 (13.4) | 3 (12.5) | 0.603 |
| Partial remission | 2 (1.2) | 0 (0.0) | 4 (3.1) | 0 (0.0) | ||
| Overall response rate | 143 (85.0) | 7 (78.0) | 0.549 | 80 (63.0) | 13 (54.0) | 0.418 |
| No remission | 19 (11.3) | 2 (22.2) | 22 (17.3) | 7 (29.2) | ||
| Death | 5 (3.0) | 0 (0.0) | 22 (17.3) | 3 (12.5) | ||
| Early death ** | 1 (0.6) | 0 (0.0) | 0.818 | 3 (2.4) | 1 (4.2) | 0.617 |
* Boldface indicates statistical significance. Early death **: Death within 28 days of initiating treatment.