Table 1.
AC regulated the levels of Ach, ChAT and AchE in the serum and brain.
| Groups | Neurotransmitters | CTRL | AC (500 mg/kg) | AlCl3 + d-gal | |||
|---|---|---|---|---|---|---|---|
| CTRL | AC (mg/kg) | ||||||
| 250 | 500 | 1000 | |||||
| Serum | Ach (μg/mL) | 115.4 ± 5.8 | 107.2 ± 6.6 | 87.2 ± 8.4 # | 98.3 ± 5.5 | 89.1 ± 3.1 | 108.8 ± 4.2 * |
| AchE (nmol/ L) | 9.7 ± 0.2 | 9.6 ± 0.1 | 11.2 ± 0.3 # | 10.7 ± 0.1 | 9.8 ± 0.2 * | 9.6 ± 0.1 * | |
| ChAT (pg/mL) | 181.6 ± 8.3 | 195.7 ± 23.2 | 163.4 ± 18.2 # | 182.7 ± 9.9 | 204.1 ± 13.7 * | 204.1 ± 15.2 * | |
| Tissue | Ach (μg/mgprot) | 2.1 ± 0.1 | 2.4 ± 0.2 | 1.3 ± 0.1 ## | 1.3 ± 0.2 | 1.2 ± 0.1 | 2.1 ± 0.2 * |
| AchE (nmol/gprot) | 0.28 ± 0.03 | 0.21 ± 0.02 | 0.47 ± 0.06 # | 0.48 ± 0.06 | 0.37 ± 0.02 * | 0.37 ± 0.05 * | |
| ChAT (pg/mgprot) | 6.9 ± 0.5 | 7.2 ± 0.3 | 5.0 ± 0.1 # | 5.1 ± 0.6 | 7.2 ± 0.3 * | 7.3 ± 0.4 * | |
28-day AC treatment strongly enhanced the levels of Ach and ChAT, and reduced the levels of AchE in serum and brain compared with non-treated AD mice. Data expressed as mean ± S.E.M. (n = 12). # p < 0.05 and ## p < 0.01 vs. control mice, * p < 0.05 vs. AD mice.