Table 1.

The binging free energy ΔG in kcal/mol of colchicine and paclitaxel with human and Colchicum autumnale tubulin.

Species	Ligand	Generalized Born ΔG (kcal/mol)	Poisson–Boltzman ΔG (kcal/mol)
Homo Sapiens	Paclitaxel	−23.25	−43.30
C. autumnale	Paclitaxel	−20.78	−44.81
Homo Sapiens	Colchicine	−51.79	−76.68
C .autumnale	Colchicine	−43.44	−64.71