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. 2017 Aug 18;18(8):1681. doi: 10.3390/ijms18081681

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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High fat-sucrose diet accelerated insulin resistance in NASH rats. The hepatic insulin resistant of SD rats induced by the high fat-sucrose diet on day 10, 20, 30, 40, 50. The blood glucose concentration of day 10 (A); day 20 (B); day 30 (C); day 40 (D); day 50 (E); total period (F); Area under the cure (AUC) of total (G). Serum insulin content (H). Homeostasis model assessment index of insulin resistance (HOMA-IR) (I). The protein expression of phospho-AKT (Ser473) (pAKT^ser473) and protein kinase B (AKT) (J). Semi-quantitative of pAKT^ser473 and AKT protein expression (K). The values are expressed as the means ± SEM (n = 6). Compared with the corresponding control group, ^# p < 0.05, ^## p < 0.01, ^### p < 0.001.