Table 1.
Mechanosensitive miRNAs screened by microarray are putatively involved in osteogenic differentiation.
| miRNAs | Mechanical Stimuli and Parameters | Microarray Groups | Samples | Reference |
|---|---|---|---|---|
| miR-218, -33, 191*, 3070a | Stretch stress (Four-point bending) 2500 µε, 0.5 Hz |
0 and 8 h | MC3T3-E1 | [41] |
| miR-3077-5p, -3090-5p, -3103-5p, -466h(i)-3p | Stretch stress (Four-point bending) 2500 με, 0.5 Hz |
0 and over 3 d (1 h/d) | MC3T3-E1 | [42] |
| miR-146b-5p | Stretch stress (Four-point bending) 2000 µε, 0.5 Hz |
0 and 18 h | OCCM-30 | [43] |
| miR-1246, -5096, -638, -663, -21, -4492, -4734, -3195, -4281, -3178 | Stretch stress (Flexcell) 10% strain, 1.0 Hz |
0 and 12 h | PDLSCs | [46] |
| miR-195-5p, -424-5p, -1297, -3607-5p, -145-5p, -4328, 224-5p | Stretch stress (Flexcell) 12% deformation 0.1 Hz |
0 and 72 h | PDLCs | [47] |
| miR-20a, -21, 199b, -34a(c), -140, -200b | FSS 12 dyn/cm2 |
0, 0.5 and 1 h | MC3T3-E1 | [48] |
d: day; FSS: Fluid shear stress; h: hour; miR: microRNA; OCCM: immortalized osteocalcin positive cementoblasts; PDLCs: periodontal ligament cells; PDLSCs: Periodontal ligament stem cells.