Table 2.
Mechanosensitive miRNAs promote osteogenic differentiation.
| miRNAs | Mechanical Stimuli | Methods | Target Gene | Samples | Reference |
|---|---|---|---|---|---|
| miR-21 | Stretch stress (Flexcell) |
10% strain 1.0 Hz 6, 12, 24, or 48 h |
Acvr2b | PDLSCs | [51] |
| miR-365 | Stretch stress (Bio-stretch) |
8% deformation, 1 Hz 15 min/h, 24 h |
Hdac4 | chondrocyte | [38] |
| miR-132 | FSS | 3, 6, 9, 12, 15 dyn/cm2, 6 h | - | PDLCs | [39] |
| miR-33-5p | FSS Unloading |
10 dyn/cm2, 1 h 24 rpm, 48 h |
Hmga2 | MC3T3-E1 | [40] |
Acvr2b: activin receptor type IIB; FSS: Fluid shear stress; Hmga2: high mobility group AT-hook 2; Hdac4: hystone deacetylase 4; PDLCs: periodontal ligament cells; PDLSCs: Periodontal ligament stem cells.