Table 1.
The cytotoxicity of ZHER2:2891-Fc-MMAE in comparison to the previously published IC50 values obtained for the ZHER2:2891-MMAE conjugate. IC50 results are expressed as mean ± SEM.
| Cytotoxic Agent | SK-BR-3 (10) * | MDA-MB-453 (8) * | T-47-D (5) * | MDA-MB-231 (2) * | |
|---|---|---|---|---|---|
| IC50 (nM) | free MMAE [19] | 1.76 ± 0.26 (n = 3) | 1.27 ± 0.46 (n = 3) | 3.25 ± 1.06 (n =3) | 5.21 ± 1.46 (n = 3) |
| ZHER2:2891-MMAE [19] | 5.16 ± 1.09 (n = 4) | 24.83 ± 5.62 (n =3) | 135.55 ± 22.7 (n = 4) | 161.53 ± 49.9 (n = 3) | |
| ZHER2:2891-Fc-MMAE | 0.13 ± 0.01 (n = 7) | 1.87 ± 0.27 (n = 4) | 45.67 ± 7.43 (n = 3) | 98.22 ± 30.9 (n = 7) |
* The erbB2 gene expression values according to HerceptinR, a database for Herceptin resistance [46].