. 2017 Aug 3;18(8):1690. doi: 10.3390/ijms18081690

Table 2.

Genotypic distributions of the LEPR analysed polymorphisms and its association with obesity in children.

Polymorphism	Function	Allele 1/Allele 2	Case			Control			Minor Allele	Minor Allele		OR (95% CI)	p	p ^a
Polymorphism	Function	Allele 1/Allele 2	11	12	22	11	12	22	Minor Allele	Case	Control	OR (95% CI)	p	p ^a
rs11208659	Intron	T/C	240	44	2	173	61	2	C	0.084	0.138	0.54 (0.35–0.81)	0.003	0.076
rs11804091	Intron	A/G	193	76	8	181	46	2	G	0.166	0.109	1.64 (1.13–2.39)	0.010	0.251
rs10157275	Intron	C/T	195	83	8	184	46	6	T	0.173	0.123	1.53 (1.08–2.18)	0.017	0.444
rs9436303	Intron	A/G	162	100	24	152	73	11	G	0.259	0.201	1.36 (1.02–1.81)	0.036	0.926
rs1627238	Intron	C/T	186	87	13	167	60	5	T	0.198	0.151	1.40 (1.01–1.94)	0.046	1
rs17412175	Intron	T/A	82	146	58	57	120	58	A	0.458	0.502	0.82 (0.64–1.06)	0.133	1
rs9436739	Intron	T/A	231	53	2	178	56	2	A	0.100	0.127	0.74 (0.50–1.10)	0.135	1
rs1137101	Gln223Arg	A/G	85	135	65	76	117	41	G	0.465	0.425	1.16 (0.91–1.48)	0.243	1
rs6673591	Intron	A/G	83	129	74	55	121	60	G	0.484	0.511	0.89 (0.70–1.13)	0.325	1
rs17412723	Intron	A/G	71	155	60	58	114	62	G	0.481	0.509	0.88 (0.68–1.14)	0.329	1
rs6697315	Intron	T/C	126	125	35	92	113	30	C	0.341	0.368	0.88 (0.68–1.14)	0.329	1
rs6704167	Intron	A/T	92	138	56	68	114	52	T	0.437	0.466	0.88 (0.69–1.13)	0.330	1
rs8179183	Lys656Asn	G/C	195	82	9	153	72	10	C	0.175	0.196	0.87 (0.63–1.19)	0.379	1
rs1327118	PRO	G/C	73	143	59	62	121	42	C	0.475	0.456	1.10 (0.85–1.43)	0.472	1
rs1137100	Lys109Arg	A/G	155	112	19	133	89	14	G	0.262	0.248	1.09 (0.82–1.45)	0.552	1
rs3806318	PRO	A/G	158	104	24	116	101	16	G	0.266	0.285	0.92 (0.70–1.21)	0.562	1
rs970468	Intron	T/G	123	135	28	96	113	26	G	0.334	0.351	0.93 (0.71–1.22)	0.588	1
rs3790429	Intron	A/T	187	93	5	161	64	8	T	0.181	0.172	1.09 (0.78–1.51)	0.630	1
rs9436740	Intron	A/T	143	115	24	119	89	26	T	0.289	0.301	0.95 (0.73–1.24)	0.704	1
rs1475397	Intron	C/T	149	118	19	122	95	19	T	0.273	0.282	0.95 (0.72–1.25)	0.712	1
rs11585329	Intron	T/G	215	64	7	171	61	4	T	0.136	0.146	0.94 (0.66–1.33)	0.718	1
rs4655802	Intron	A/G	92	133	55	74	111	41	G	0.434	0.427	1.03 (0.80–1.32)	0.828	1
rs6678033	Intron	G/A	107	136	43	91	111	34	A	0.388	0.379	1.03 (0.80–1.33)	0.829	1
rs6672331	Intron	G/C	273	13	0	224	12	0	C	0.023	0.025	0.94 (0.42–2.12)	0.886	1
rs1137099	Thr85Ala	A/	286	0	0	236	0	0		0	0	-	-	-
rs13306526	Ile503Val	A/	286	0	0	236	0	0		0	0	-	-	-

CI: confidence interval; OR: odds ratio; PRO: promoter. OR adjusted for age, sex and Tanner stage under the additive model. ^a p values after Bonferroni correction. The bold is the statistic significance for the rows where p is lower than 0.05.