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. 2017 Aug 4;18(8):1710. doi: 10.3390/ijms18081710

Figure 1.

Figure 1

Tunicamycin induced hepatic endoplasmic reticulum (ER) stress and impaired liver function. 7-month-old mice were injected intraperitoneally with vehicle or 1 mg/kg tunicamycin. Livers were collected 24 h after injection under fed condition. N = 6 per group. (A) Liver weight at harvest; (B) Liver morphology; (C) Phosphorylation level of PERK in the liver; (D) Expression levels of ER stress indicator genes in the liver; (E) Serum level of AST; (F) Serum level of ALT; (G) The ratio of serum AST to ALT. Data were shown as mean ± SEM. Veh, vehicle; TM, tunicamycin. * p < 0.05, ** p < 0.01, *** p < 0.001 TM vs. Veh.