Table 1.

Top 10 annotation terms with the highest FDR in enrichment analysis of protein clusters A and B from unsupervised hierarchical clustering. (GOCC = GeneOntology cell compartment; KEGG = Kyoto Encyclopedia of Genes and Genomes; GOBP = GeneOntology biological process; GOMF = GeneOntology molecular function.)

Type	Name	p-Value	Enrichment	Total	In Cluster	Cluster Size	Benj. Hoch. FDR
Cluster A: Significantly Higher Protein Levels in Post-flight Group
GOCC name	Ribonucleoprotein complex	1.62 × 10−14	1.92	55	52	218	1.90 × 10−12
KEGG name	Ribosome	1.70 × 10−11	1.97	38	37	218	3.13 × 10−9
GOBP name	Cellular amino acid metabolic process	2.23 × 10−12	1.82	59	53	218	7.79 × 10−9
GOBP name	Cellular nitrogen compound metabolic process	1.07 × 10−11	1.54	116	88	218	1.87 × 10−8
GOMF name	Structural constituent of ribosome	3.68 × 10−11	1.97	37	36	218	3.37 × 10−8
GOBP name	Nitrogen compound metabolic process	3.29 × 10−11	1.52	119	89	218	3.83 × 10−8
GOCC name	Mitochondrial matrix	1.69 × 10−9	1.91	36	34	218	9.86 × 10−8
GOBP name	Cellular amine metabolic process	6.56 × 10−10	1.71	63	53	218	5.73 × 10−7
GOBP name	Translation	1.69 × 10−9	1.91	36	34	218	9.81 × 10−7
GOBP name	Macromolecule biosynthetic process	1.41 × 10−9	1.76	53	46	218	9.84 × 10−7
Cluster B: Significantly Lower Protein Levels in Post-flight Group
GOCC name	Membrane part	1.04 × 10−30	1.65	173	145	224	4.85 × 10−28
GOCC name	Intrinsic to membrane	6.62 × 10−23	1.80	102	93	224	1.03 × 10−20
GOCC name	Integral to membrane	6.62 × 10−23	1.80	102	93	224	1.55 × 10−20
GOCC name	Organelle membrane	3.49 × 10−14	1.47	157	117	224	3.26 × 10−12
GOCC name	Endoplasmic reticulum part	7.21 × 10−12	1.72	69	60	224	5.63 × 10−10
GOCC name	Endoplasmic reticulum	5.52 × 10−11	1.84	46	43	224	3.69 × 10−9
GOCC name	Endoplasmic reticulum membrane	2.47 × 10−9	1.72	54	47	224	1.28 × 10−7
GOCC name	Plasma membrane part	5.85 × 10−8	1.67	52	44	224	2.74 × 10−6
GOCC name	Membrane	4.95 × 10−7	1.19	260	157	224	2.10 × 10−5
GOMF name	Transporter activity	1.46 × 10−6	1.78	31	28	224	2.67 × 10−4