Primary or DE blepharitis syndrome (DEBS). Secondary to skin diseases such as rosacea, psoriasis, lupus, ichthyosis, rheumatoid arthritis, etc. |
Oxidative stress, aging and/or associated factors. Corneal hypoesthesia. Systemic/topical medications, conjunctivochalasis, abnormal eyelid position, etc. |
Hormonal changes, menopause, pregnancy. Allergic diseases, bacterial or viral conjunctivitis, use of contact lenses or computer, ocular surface trauma or tumor or surgery, environmental factors, etc. |
Autoimmune pathologies: Sjögren’s syndrome dry eye (SS). Non-Sjögren’s syndrome dry eye (non-SSDE) |
Stevens Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), graft-versus-host disease (GVHD). Neurotrophic deficiencies, Keratoconus (KC), pinguecula, pterygium, corneal dystrophies, etc. |