Table 2.

Dry eye (DE) classification according to pathogenetic analysis in ocular surface disorders.

Meibomian Glands Dysfunction	Principal Mixed Forms	Other Major Mixed Forms	Aqueous Deficits	Ocular Surface Diseases
Primary or DE blepharitis syndrome (DEBS). Secondary to skin diseases such as rosacea, psoriasis, lupus, ichthyosis, rheumatoid arthritis, etc.	Oxidative stress, aging and/or associated factors. Corneal hypoesthesia. Systemic/topical medications, conjunctivochalasis, abnormal eyelid position, etc.	Hormonal changes, menopause, pregnancy. Allergic diseases, bacterial or viral conjunctivitis, use of contact lenses or computer, ocular surface trauma or tumor or surgery, environmental factors, etc.	Autoimmune pathologies: Sjögren’s syndrome dry eye (SS). Non-Sjögren’s syndrome dry eye (non-SSDE)	Stevens Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), graft-versus-host disease (GVHD). Neurotrophic deficiencies, Keratoconus (KC), pinguecula, pterygium, corneal dystrophies, etc.