Figure 2.

Location of frequently mutated or downregulated epigenome modifier genes including PBRM1, BAP1, SETD2, KDM5C and KDM6A in ccRCC. Chromosome 3p contains a ~50 Mbs region where four of these TSGs are located next to each other. Moreover, KDM5C and KDM6A are located on X chromosome but escape X-inactivation (EXITS). KDM5D and KDM6C, that are located on the Y chromosome, are homologs of KDM5C and KDM6A respectively. Interestingly, these chromosome Y homologs of the X-lined genes are commonly deleted in male patients affected by ccRCC. Figure not drawn to scale. Pink, Centromere; Black, G-positive band; White, G-negative band; Gray, G-positive band (with increasing gray color intensity indicating increasing positive band 25–75%); and Purple, variable region.