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. 2017 Aug 16;18(8):1774. doi: 10.3390/ijms18081774

Figure 3.

Figure 3

Role of BAP1 in regulation of polycomb target genes. Polycomb Repressive Complex (PRC) 2 mediates H3K27 trimethylation that triggers recruitment of PRC1 complex to H2K27me3 sites where PRC1 complex silences gene expression through monoubiquitylation of H2AK119. In normal conditions, BAP1 can contribute to the removal of ubiquitin from H2AK119ub, establishing a balance between ubiquitination and deubiquitination of H2AK119ub that regulates expression of polycomb target genes. This balance is disrupted when BAP1 is mutated in ccRCC, resulting in dysregulation of polycomb target genes.