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3D Modeling of the α1, α2 and α3 domains of human HLA-C*12:02:02 in complex with peptide. (A) The residues colored in red represent the unique amino acid polymorphisms Ala73, Trp156 and Arg219 of HLA-C*12:02:02 compared to HLA-C*01:02:01 and HLA-C*03:02:01. (B) View from the top of (A). The Ala73 and Trp156 polymorphisms are located in the peptide-binding groove between the α1 and α2 domains and interact with the peptide presented by HLA-C*12:02:02.
