Table 2.
Up- or down-regulated factors produced by ASCs cultured in STK2.
| Name | Function | |
|---|---|---|
| Up | Adiponectin | regulate glucose levels, fatty acid breakdown, adipocyte differentiation |
| Angiogenin | induce angiogenesis | |
| Cystatin C | induce proliferation of neural stem cell | |
| DKK_1 | inhibit WNT signaling pathway | |
| EMMPRIN | induce matrix metalloproteinase synthesis | |
| CD105 | mediate TGFβ signal | |
| FGF-19 | regulate cell proliferation, glucose and bile acid metabolism | |
| G-CSF | induce mesenchymal cell mobilization | |
| GDF-15 | regulate inflammatory and apoptotic pathways in injured tissues | |
| GM-CSF | promote proliferation of human fetal and adult microglia | |
| M-CSF | regulate the survival, proliferation and differentiation of hematopoietic precursor cells | |
| HGF | promote progenitor cell mobilization, induce angiogenesis and cell proliferation, inhibit immune cell proliferation | |
| CD54 | induce MSC-mediated immunosuppression | |
| IGFBP-2 | promote cell mobility and osteoblast differentiation | |
| IL-1ra | inhibit the pro-inflammatory effect of IL-1β | |
| Lipocalin-2 | protect MSC against unfavorable microenvironments and decrease MSC senescence | |
| CCL-7/MCP-3 | induce MSC migration and recruit MSC to site of injured tissue | |
| MIF | Induce MSC migration and promote cell proliferation of neural stem/progenitor cell | |
| CCL3 | induce MSC migration and recruit MSC to site of injured tissue | |
| CCL-20 | inhibit T cell activation and proliferation and induce MSC migration | |
| PDGF-AA | induce MSC migration and promote osteogenic differentiation | |
| MMP-9 | ECM remodeling and cell migration | |
| TSF-14 | inhibit atherosclerosis and protect cardiac function | |
| CXCL4 | protect MSC from acute radiation injury and maintain HSC stemness | |
| TFF3 | decrease IL-6 and IL-8 | |
| Thrombospondin-1 | induce MSC differentiation | |
| uPAR | inhibit tumor growth and induce chemotaxis of CD34+ hematopoietic stem cell | |
| Down | FGF-7 | reduce IL-1β and TNFα, and increase IL-10 |
| IGFBP-3 | induce cellular senescence | |
| IL-11 | induce inflammation to cancer progression and function as tumor promoting cytokine |