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. 2017 Aug 22;18(8):1827. doi: 10.3390/ijms18081827

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Systemic chemokine levels in 11 inflammatory bowel disease-patients previously non-responding to anti-TNF-agents before and at week 10 after induction therapy with vedolizumab. (A) Serum levels of in total 21 chemokines in IBD-patients at baseline (week 0) and after (week 10) treatment with vedolizumab analyzed by multiplexed proximity extension assay (PEA). Serum levels of individual chemokines; (B) CCL13 (MCP-4); (C) CXCL8 (IL-8); (D) CCL20 (LARC); (E) CXCL1 (GRO-α); (F) CCL23 (MPIF-1); (G) CCL28 (MEC) divided by the clinical response into responders and non-responders. Data represent normalized protein expression (NPX) in a log2 scale mean + SEM, * p < 0.05; ** p < 0.01, paired Student’s t-test; Of IBD-patients six were responders and five non-responders.