Table 2.
Summary of the nano cellulose-based materials tested in wound healing.
| Type of Cellulose | Material Realesed | In Vitro Tests | In Vivo Tests | Molecular Effects | References |
|---|---|---|---|---|---|
| PLGA/CNC/CMCS | Cur and ANG | HUVEC cells | Skin full-thickness burn Rat model | Increase of ANG expression, improving wound healing | Mo et al. [70] |
| Cur/GMs/Col-CNC scaffold | Curcumin | Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa | Skin full-thickness burn rat model in which the dorsal skin was artificially burned and infected with Pseudomonas aeruginosa | in vitro: antimicrobial activity; in vivo: exhibited higher epithelializing rates |
Guo et al. [73] |
| NFC- PEOx-PPOy-PEOx | Octenidine | Vertical diffusion cells and antimicrobial tests | Down regulation of bacterial infection | Alkhatib et al. [74] | |
| NFC | Zinc oxide (ZnO) | Skin burn mice model | Enhanced wound healing and tissue regeneration activity | Khalid et al. [76] | |
| NFC-X | hASC cells | The cells adhere, migrate and proliferate properly | Mertaniemi et al [79] |
PLGA/CNC/CMCS = poly(lactic-co-glycolic acid)/cellulose nanocrystals/carboxymethyl chitosan; Cur = curcumin; ANG = angiogenin; Cur/GMs/Col-CNC = Curcumin/gelatin microspheres/collagen/cellulose nanocrystal; NFC- PEOx-PPOy-PEOx = nanofibrillar bacterial cellulose/polyethylene oxide (PEO)/polypropylene oxide (PPO) arranged in a triblock structure; NFC-X = nanofibrillar cellulose with glutaraldehyde cross-links; hASC = human adipose mesenchymal stem cells.