Table 6.
Summary of the nano cellulose-based materials tested in “other applications”.
| Type of Cellulose | Material Realesed | In Vitro Tests | In Vivo Tests | Molecular Effects | References |
|---|---|---|---|---|---|
| NFC | Bendamustine | Swelling tests at different pH | Rat model | Good drug loading and release | Bhandari et al. [109] |
| NFC/RS/P | Methotrexate | In vitro: good delivery and permanence in the colon mucosa | Meneguin et al. [110] | ||
| NFC | Metformin | B16F10 cells | Reduction of the migration, invasion and ashesion of B16F10 cells | Nurani et al. [112] | |
| Si-HPMC | hASCs | Rat model | Colonic biological conditions improving in rats with colon damage | Moussa et al. [114] | |
| CNC-PEI | siRNA | C2C12 murine myoblastic cells | Decrease of the cells growth (anti-proliferative) | Ndong Ntoutoume et al. [126] | |
| HEC-PEG | siRNA | Muco-adhesive properties | Furst et al. [128] | ||
| CMC/β-C/AA | Acyclovir | Swelling tests at different pH | Basic pH favors the maximal swelling of the CMC/β-C/AA releasing acyclovir in the small intestine | Malik et al. [131] |
NFC = Cellulose in form of nanofibers; Si-HPMC = silane-hydroxyl-propylmethyl cellulose; hASC = human adipose mesenchymal stem cells; NFC/RS/P = cellulose nanofibrils/resistant starch/pectin; CMC/β-C/AA = CMC/β-cyclodextrin/acrylic acid; EC-MC = ethyl cellulose-methyl cellulose; CNC-PEI = cellulose nanocrystals-Polyethylenimine; HEC-PEG = hydroxyethyl cellulose-polyethylene glycol; siRNA = small interference RNA.