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Superimposition of IKKα (white) and IKKβ (blue) highlighting the differences near/in the ATP binding site (marked by the staurosporine analogue as a stick model) between the two isoforms. The expanded area shows equivalent residues in IKKα (Asn28, Leu48, and Thr52) and IKKβ (Asn28, Gln48, and Pro52) engaged in different interactions/structural effects, resulting in Asn28 being available to interact with putative ligands in the binding pocket of IKKα but not IKKβ.
