Figure 4. Phylogenetic profile and network visualization of human mitochondrial proteome.

(A) Phylogenetic profile plot for 1,006 human mitochondrial proteins across 972 fully sequenced organisms. Blue and grey squares indicate the gene gain and loss, respectively. Hierarchical cluster is applied to both the organisms (columns) and proteins (rows). The organisms are organised into 6 taxa: Animals, Plants, Fungi, Protista, Bacteria, and Archaea. On the left, each small band indicates the corresponding subunits in complex I to V, and MRPs. (B) Predicted linkage network for human mitochondria proteins.