Figure 3.
Recruitment of kinesin-1 inhibits accumulation of pigment granules in the cell center induced by pigment aggregation signals. Phase contrast images of melanophores co-expressing kinesin-1-EGFP- FRB and TRP-1-FKBP-mCherry treated with MSH (left images) or melatonin (right images) in the absence (top row) or presence (bottom row) of rapalog; rapalog treatment that recruits kinesin-1 to pigment granules inhibits their aggregation in the cell center. Numbers indicate time in minutes. Scale bar, 5 μm.