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. Author manuscript; available in PMC: 2017 Aug 31.
Published in final edited form as: Circ Res. 2016 May 19;119(1):55–68. doi: 10.1161/CIRCRESAHA.116.308304

Figure 1. CD74 is downregulated in preeclamptic placenta.

Figure 1

A) CD74 expression is downregulated in placentas of preeclamptic women (PE) compared to healthy women (control; n=28). PE is subdivided in early onset PE (delivery <34 week of gestation; grey bar; n=26) and late onset PE (delivery ≥34 week of gestation; black bar; n=24) (**p<0.01; ***p<0.001; Bonferroni’s multiple comparisons test). B) CD74 protein (33 and 35 kDa) is lowered in placenta lysates of early and late onset PE (n=2 each). C) Confirmation by flow cytometry; representative CD74-positive gating is shown for whole placenta cell population (left panel). Mean fluorescent intensity (MFI) of CD74 is lowered in general placenta cell population of late PE vs. control (right panel) (n=10 (PE) and 6 (control); ***p=0.001; Mann Whitney test).