Table 2.

Recipient Post–Lung Transplant Outcomes in EVLP Arm

EVLP number	Age (years)/sex	Diagnosis	High risk	Tx	CPB	Pao2/Fio2 ratio at 24 hours post-Tx (mm Hg)	PGD score at 72 hours	Post-operative ECMO	Invasive ventilation, days	ICU stay (days)	Hospital stay (days)	Survival to discharge	1-year survival	Cause of death
27	59/M	IPF	No	Yes—DL	Yes	378	0	No	2	3.5	46	Yes	Yes
28	32/F	CF	NIV	Yes—DL	No	217	3	No	1.5	7.5	21	Yes	Yes
29	56/M	COPD	NIV	Yes—DL	Yes	335	1	Yes	15	15	25	Yes	No	Pneumonia
30	62/F	IPF	NIV	Yes—SL	Yes	428 (ECMO)	3	Yes	65	65.5	93	Yes	Yes
31	44/M	PAH	PAH	Yes—DL	Yes	221	3	Yes	0.33	21	44	Yes	Yes
32	48/M	IPF	RV↓	Yes—DL	Yes	286	1	No	0.5	1.5	16	Yes	Yes
33	49/M	IPF	No	Yes—DL	Yes	326 (ECMO)	2	Yes	70	68	87	Yes	Yes
34	59/F	COPD	No	Yes—DL	Yes	146	1	No	1.5	5	25	Yes	Yes
35	64/M	COPD	NIV	Yes—DL	No	278	2	No	0.5	2.5	16	Yes	Yes
36	20/M	CF	NIV	Yes—DL	Yes	203	2	No	2.5	6.5	17	Yes	Yes
37	60/M	COPD	No	Yes—DL	Yes	345	1	No	1.5	5.5	25	Yes	Yes
38	56/M	IPF	No	Yes—DL	Yes	113 (ECMO)	3	Yes	100a	98	100a	No	No	PGDb and sepsis
39	56/F	BE	No	Yes—DL	Yes	257	1	No	3	14	31a	No	No	Pneumonia and sepsis
40	56F	COPD	No	Yes—DL	Yes	401	2	No	18a	18a	18a	No	No	PGDb and hypoxic brain injury
41	23/M	CF	NIV + RV↓	Yes—DL	Yes	368 (ECMO)	1	Yes	3	15	63a	No	No	PGDb and pneumonia
42	58/M	IPF	NIV	Yes—SL	Yes	71	3	No	31a	31a	31a	No	No	PGDb and respiratory arrest

BE, bronchiectasis; CF, cystic fibrosis; COPD, chronic obstructive pulmonary disease; CPB, cardiopulmonary bypass; DL, double-lung; ECMO, extracorporeal membrane oxygenation; EVLP, ex vivo lung perfusion; F, female; ICU, intensive care unit; IPF, idiopathic pulmonary fibrosis; M, male; NIV, non-invasive ventilation; PAH, pulmonary artery hypertension; Pao₂/Fio₂, arterial oxygen partial pressure/fraction of inspired oxygen; PGD, primary graft dysfunction; RV↓, right ventricular failure; SL, single-lung; Tx, transplantation.

^aDeath before hospital discharge.

^bOf 4 recipients in whom we believe PGD played a role in the cause of death, 2 had severe PGD at all time points up to 72 hours. One patient had very severe graft failure on arrival in the ICU and had to be salvaged with emergency ECMO. ECMO was weaned just before 72 hours and the patient had at this time point a saturation reflecting mild PGD, even though he never recovered and continued to need hospital treatment for failing graft function until his death at 63 days post-Tx. The fourth recipient had moderately severe PGD up to 72 hours, which never recovered. The patient was never weaned off invasive ventilation and died 18 days post-transplant.