Fig 1. The conceptual model.
Light gray boxes (symbolized x0, x1, y0, and y1) illustrate the compartments of the basic model, and the black arrows the rates of the flows between these compartments. Here x0 denotes the number of HSC, x1 that of HMS, y0 that of MPN SC, and y1 the number of MPN MC. The light blue compartment (symbolized a) contains all dead cells and the light orange compartment (symbolized s) the inflammatory level, i.e. the immune response. Blue arrows from these represent related rates of flows. Red stipulated arrows going from the inflammatory compartment represent effects of the cytokines (or neutrophils when eliminating dead cells) modulating rates of the basic model. Two additional rates (depending on x0 and y0) appearing as red stipulated arrows represent the bone marrow niches symbiosis with the stem cells modulating the self-renewal rates. Note, stem cells leaving their respective compartments enter the corresponding mature cell-pools as multiplied by the progenitor amplification factor (A).