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. 2017 Aug 31;12(8):e0183620. doi: 10.1371/journal.pone.0183620

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© 2017 Andersen et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 2 — A) Plateaus to the left show the amount of hematopoietic stem cells x₀ (upper plateau) and that for MPN stem cells y₀ (lower plateau) whereas the plateaus to the right show the amount of hematopoietic stem cells x₀(lower plateau) and MPN mature cells y₀ (upper plateau). B) Plateaus to the left show the amount of hematopoietic mature cells x₁ (upper plateau) and that for MPN mature cells y₁ (lower plateau) whereas the plateaus to the right show the amount of hematopoietic mature cells x₁ (lower plateau) and MPN mature cells y₁ (upper plateau). The yellow and purple boxes show our data used for calibrating (and validating) the model with further details in S1 Appendix. Yellow boxes show our “no MPN cancer values”, and purple boxes show our “full blown” MPN values in the advanced myelofibrosis stage. Yellow position marker shows the number of hematopoietic stem cells as used by Dingli & Michor [92], and black position markers show the number of cells as used by Gentry et al. [86].