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. 2017 Aug 31;12(8):e0184028. doi: 10.1371/journal.pone.0184028

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© 2017 Maccarana et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 2 — (A) Asporin immunoblotting of dorsal skin extracts from three wild-type and three Aspn^-/- mice. (B) 2 month-old female dorsal skins were analyzed histologically by staining with Massson Trichrome, or (C) by immunohistochemistry by staining for the presence of CD31-positive blood vessels and F4/80-positive macrophages; bars in A and B are 100 μm. Similar results were obtained from analyses of six mice from each genotype. (D) Transmission electron microscopy on cross-sectioned collagen fibrils in reticular dermis. (E) Transmission electron microscopy on longitudinally oriented collagen fibrils in reticular dermis. Bars in C and D are 200 nm. (F) Quantification of collagen fibril diameter in reticular dermis. 1,000 fibrils were measured from electron microscopy images collected from six wild-type and six Aspn^-/- mice.