TABLE 1.
Demographics of a total of 89 SD patients assigned to different groups based on their phenotypes and putative genotypes
| Sporadic versus familial
|
Sporadic versus familial
|
ADSD versus ABSD
|
ADSD versus ABSD
|
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|---|---|---|---|---|---|---|---|---|
| Homogeneous group
|
Heterogeneous group
|
Homogeneous group
|
Heterogeneous group
|
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| Sporadic | Familial | Sporadic | Familial | ADSD | ABSD | ADSD | ABSD | |
| n | 23 (AD) | 22 (AD) | 30 (7AB/23AD) | 29 (7AB/22AD) | 30 (SPOR) | 30 (SPOR) | 37 (30SPOR/7FAM) | 37 (30SPOR/7FAM) |
| Sex, female/male | 18/5 | 19/3 | 24/6 | 24/5 | 23/7 | 26/4 | 29/8 | 31/6 |
| Age (y), mean ± s.d. | 56 ± 11 | 56 ± 15 | 56 ± 12 | 56 ± 15 | 56 ± 12 | 53 ± 13 | 56 ± 13 | 54 ± 12 |
| SD duration, mean ± s.d. | 14 ± 11 | 21 ± 14 | 16 ± 13 | 20 ± 14 | 17 ± 13 | 15 ± 9 | 17 ± 12 | 16 + 11 |
| Age of onset (y), mean ± s.d. | 42 ± 13 | 35 ± 16 | 40 ± 13 | 36 ± 17 | 39 ± 16 | 38 ± 12 | 39 ± 17 | 38 ± 12 |
| Handedness (Edinburgh Inventory) | Right | |||||||
| Language | Monolingual native English | |||||||
| Cognitive status | Mini-Mental State Examination ≥ 27 points | |||||||
| Genetic status | Negative for DYT1, DYT6, DYT4, and DYT25 | |||||||
FAM, familial; SPOR, sporadic.