TABLE 2.
Statistically significant differences in cortical thickness and fractional anisotropy between ABSD and ADSD as well as familial and sporadic SD patients
| ADSD versus ABSD | ||||
|---|---|---|---|---|
|
| ||||
| Homogeneous group (sporadic only) | ||||
| Cortical thickness | Region | t score | Coordinates (x,y,z) | Area (mm2) |
| L sensorimotor (laryngeal/orofacial) | 3.9 | −47 −10 31 | 94 | |
| L angular gyrus | 3.8 | −46 −69 22 | 83 | |
| L sensorimotor (respiratory) | 3.6 | −16 −32 59 | 81 | |
| Fractional anisotropy | Region | t score | Coordinates (x,y,z) | Cluster size |
| R superior corona radiata (csp, cpt, str) | 4.83 | 20, −19, 39 | 295 | |
| R corpus callosum (splenium) | 4.62 | 22, −50, 21 | 236 | |
| Heterogeneous group (sporadic + familial) | ||||
| Cortical thickness | Region | t score | Coordinates (x,y,z) | Area (mm2) |
| L angular gyrus | 4.1 | −4 −69 22 | 103 | |
| L sensorimotor (respiration) | 3.4 | −14 −32 61 | 86 | |
| L insula | 3.5 | −56 | 81 | |
| Fractional anisotropy | Region | t score | Coordinates (x,y,z) | Cluster size |
| R superior corona radiata (csp, cpt, str) | 4.56 | 20 −18 39 | 236 | |
| Sporadic SD versus familial SD | ||||
|---|---|---|---|---|
|
| ||||
| Homogeneous group (ADSD only) | ||||
| Cortical thickness | Region | t score | Coordinates (x,y,z) | Area (mm2) |
| L superior temporal gyrus | 4 | −77 | 193 | |
| R insula | 3.2 | 42 −8 1 | 161 | |
| R SMA | 3.2 | 3 −25 72 | 82 | |
| Fractional anisotropy | Region | t score | Coordinates (x,y,z) | Cluster size |
| R sagittal stratum (ifo/ilf, ptr) | 4.2 | 42, −33, −11 | 84 | |
| L superior longitudinal fasciculus | −4.2 | −44, −34, 33 | 53 | |
| Heterogeneous group (ADSD + ABSD) | ||||
| Cortical thickness | Region | t score | Coordinates (x,y,z) | Area (mm2) |
| L superior temporal gyrus | 4.3 | −77 | 224 | |
| R middle temporal gyrus | 3 | 67 −31 −15 | 132 | |
| R SMA | 3.3 | 4 −25 73 | 91 | |
| Fractional anisotropy | Region | t score | Coordinates (x,y,z) | Cluster size |
| L superior longitudinal fasciculus | −4.02 | −44 −35 33 | 91 | |
For each significant cluster in the CT analyses, peaks of t-test score, P value, peak coordinates, area (mm2, CT analyses), and cluster size (FA analyses) are reported.
ifo, inferior fronto-occipital fasciculus; ilf, inferior longitudinal fasciculus; ptr, posterior thalamic radiation; csp, corticospinal tract; cpt, corticopontine tract; str, superior thalamic radiation; CC, corpus callosum; L, left hemisphere; R, right hemisphere.