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. Author manuscript; available in PMC: 2018 Sep 10.
Published in final edited form as: AIDS. 2017 Sep 10;31(14):F9–F17. doi: 10.1097/QAD.0000000000001595

Figure 3. Aging and neuron-derived exosome (NDE) proteins.

Figure 3

(a) Aging correlated with higher exosome counts in NDE from individuals with HIV. The units were log10 transformed exosome counts x109 per milliliter plasma. (b) High mobility group box 1 (HMGB1) decreased significantly with age in NDE from HIV infection; neurofilament-light (NF-L), amyloid beta (Aβ) and tetraspanins CD63 and CD81 were trending decrease with age in HIV infection. No effect was seen in NDE isolated from controls. The range of ages in controls (51–65 years) was narrower than HIV (35–67 years). Exosome protein levels were log10 transformed. Non-parametric Spearman correlation was used.