Table 1.
Hazard ratios with 95% confidence intervals for the association of birth weight with coronary heart disease, stroke, and total cardiovascular disease, nurses' health study, 1992-2000
Birth weight (g)
|
|||||||
---|---|---|---|---|---|---|---|
<2268 | 2268-2495 | >2495-3175 | >3175-3856 | >3856-4536 | >4536 | Per kg, across all categories | |
Coronary heart disease | |||||||
Events | 21 | 59 | 329 | 392 | 91 | 26 | 918 |
Person years | 8493 | 25 174 | 158 727 | 237 378 | 58 718 | 12 518 | 501 008 |
Adjusted hazard ratio: | |||||||
For age | 1.31 (0.84 to 2.04) | 1.48 (1.12 to 1.95) | 1.26 (1.09 to 1.46) | 1.00 | 0.86 (0.68 to 1.08) | 0.98 (0.66 to 1.46) | 0.77 (0.69 to 0.87) |
For age and BMI | 1.31 (0.84 to 2.03) | 1.50 (1.14 to 1.98) | 1.30 (1.12 to 1.51) | 1.00 | 0.84 (0.67 to 1.06) | 0.93 (0.63 to 1.39) | 0.75 (0.67 to 0.84) |
Stroke | |||||||
Events | 18 | 36 | 259 | 349 | 75 | 32 | 769 |
Adjusted hazard ratio: | |||||||
For age | 1.23 (0.76 to 1.98) | 1.04 (0.74 to 1.46) | 1.13 (0.96 to 1.33) | 1.00 | 0.78 (0.60 to 1.00) | 1.32 (0.92 to 1.91) | 0.89 (0.78 to 1.01) |
For age and BMI* | 1.23 (0.76 to 1.98) | 1.05 (0.74 to 1.48) | 1.16 (0.98 to 1.36) | 1.00 | 0.77 (0.60 to 0.99) | 1.28 (0.89 to 1.85) | 0.87 (0.76 to 0.99) |
Total cardiovascular disease | |||||||
Events | 39 | 95 | 588 | 741 | 166 | 58 | 1687 |
Adjusted hazard ratio: | |||||||
For age | 1.27 (0.92 to 1.76) | 1.27 (1.03 to 1.58) | 1.20 (1.08 to 1.34) | 1.00 | 0.82 (0.69 to 0.97) | 1.14 (0.87 to 1.50) | 0.82 (0.75 to 0.90) |
For age and BMI* | 1.27 (0.92 to 1.76) | 1.29 (1.04 to 1.60) | 1.23 (1.10 to 1.37) | 1.00 | 0.81 (0.68 to 0.95) | 1.10 (0.84 to 1.43) | 0.80 (0.74 to 0.88) |
BMI=body mass index.