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. Author manuscript; available in PMC: 2018 Jan 17.
Published in final edited form as: Nat Methods. 2017 Jul 17;14(9):915–920. doi: 10.1038/nmeth.4366

Figure 2.

Figure 2

Reconstruction of complex events. (a – c) Read clouds that support a complex event in the sarcoma. Clouds, colored as in Figure 1, tile across 5 consecutive breakpoints (a) with consistent copy number profiles (b). Circos plot with arcs depicting breakpoint connections illustrates that the event connects distant segments from the long arm of chromosome 12 (c). From outside to inside, chromosome ideogram (green indicates the location of the centromere), then copy number profiles, then copy number aberration calls (blue for amplifications, red for deletions) are shown. (d – f) A complex event in cell line HCC1143 (d) and its corresponding sequence read coverage (e, f).