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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Oncogene. 2017 May 1;36(35):4987–4996. doi: 10.1038/onc.2017.107

Figure 4. Loss of the vascular endothelial cell insulin receptor enhances tumor formation.

Figure 4

EndoIRKO-Min mice (“E”) and their littermate controls (“c”) were fed a regular chow diet and sacrificed at 16 weeks of age. A. The entire small intestine from two littermates. Adenomas are clearly visible as pale, circular lesions. B. Total number of tumors in the small intestine from EndoIRKO-Min mice (n=12) and controls (n=13). *, p=0.002. C. Total tumor area. *, p=0.02. D. Distribution of tumor number by diameter. E. Representative microphotos of CD31 immunohistochemistry in small intestinal tumors. Scale bar, 100 μm. F. Quantitation of tumor vascular density based on CD31 immunohistochemistry.