Table 4.
Distribution of pathogens associated with early and late-onset culture proven sepsis1/
| Pathogen | Age at Enrollment | Overall | Deaths (n) | |||
|---|---|---|---|---|---|---|
| 0–3 days | 4–7 days | 8–28 days | 29–60 days | |||
| Gram negative organisms | 5 | 14 | 25 | 14 | 58 | 5 |
| Klebsiella2/ | 2 | 9 | 18 | 8 | 37 | 2 |
| E. coli 3/ | 1 | 2 | 5 | 3 | 11 | 0 |
| Other Gram negatives4/ | 2 | 3 | 2 | 3 | 10 | 3 |
| Gram positive organisms | 0 | 2 | 10 | 10 | 22 | 1 |
| Staphylococcus aureus | 0 | 2 | 9 | 10 | 21 | 1 |
| Other Gram positives5/ | 0 | 0 | 1 | 0 | 1 | 0 |
| Fungi | 0 | 1 | 0 | 0 | 1 | 0 |
| Candida | 0 | 1 | 0 | 0 | 1 | 0 |
| Mixed infections6/ | 0 | 0 | 2 | 1 | 3 | 0 |
| Total # infants with a +BC | 5 | 17 | 37 | 257/ | 84 | 6 |
Number of infants with a positive blood culture and infant deaths are shown by pathogen type. Most infants were admitted to the hospital for suspected sepsis only once during the 60 day study period; 23 infants were admitted twice. Pathogens are shown for 81 infants with a positive blood culture on first admission (80 were enrolled only once; 1 infant was enrolled twice with a positive blood culture on first admission but not on second admission), and for three infants with negative blood cultures on first admission but a positive blood culture on the second admission.
Includes Klebsiella sp. (22), K. pneumoniae (13), K. ornithinolytica (1), K. oxytoca (1). One infant with Klebsiella sp. on blood culture on day 12 of life also had a CSF culture positive for aerobic Gram negative rods and died the day after admission.
One infant with E. coli on blood culture on day 4 of life also had a CSF culture positive for Pseudomonas aeruginosa.
Other Gram negatives includes Aeromonas hydrophila (2), Citrobacter freundii (1), Enterobacter cloacae (1), Flavobacterium oryzihabitans (2), Pasteurella pneumotropica (1), Proteus vulgaris (1), Providencia sp. (1), and Stenotrophomonas maltophila (1). The infant with Citrobacter freundii on blood culture on day 4 of life also had a CSF culture positive for aerobic Gram negative rods and died 3 days after admission.
Other Gram positives includes Streptococcus sp. [including enterococcus] (1).
Includes Klebsiella pneumoniae + E.coli (1), Klebsiella sp. + Streptococcus sp. (1), E. coli + S. aureus (1).
Includes 3 infants with a blood culture positive for S. aureus on second admission (negative blood culture at first admission).