. Author manuscript; available in PMC: 2018 Sep 1.

Published in final edited form as: Clin Exp Allergy. 2017 Jun 19;47(9):1185–1192. doi: 10.1111/cea.12956

Table 4.

Associations between FLG expression and repeated measurements of eczema^*

	Eczema, Median (IQR)		Sex-adjusted model^†		FLG adjusted model^‡

FLG probe ID	Yes (k = 39)	No (k = 212)	RR (95% CI)	P value	RR (95% CI)	P value
*Sense transcripts*
A_24_P51322	−0.61 (1.19)	0.22 (1.15)	0.54 (0.33–0.89)	0.015	0.60 (0.38–0.95)	0.047
A_32_P387648	−0.22 (1.11)	0.05 (0.97)	0.83 (0.55–1.25)	0.373	0.95 (0.63–1.41)	0.782
A_33_P3261328	−0.14 (0.27)	0.01 (0.66)	0.60 (0.34–1.07)	0.077	0.67 (0.45–1.01)	0.058
*Antisense transcripts*
A_21_P0014075	0.07 (0.74)	−0.01 (0.83)	2.02 (1.20–3.41)	0.008	2.02 (1.10–3.72)	0.024
A_33_P3296200	−0.26 (1.14)	0.11 (0.93)	0.79 (0.47–1.32)	0.366	0.94 (0.56–1.57)	0.811

k, number of repeated measurements; FLG, filaggrin; ID, identification; IQR, interquartile range; RR, risk ratio; CI, confidence interval.

Eczema was repeatedly measured at ages 3−, 6−, and 12-months. Generalized estimating equations (GEE) method was applied to account for the correlated observations.