Table 1.
Antibody alternatives for use as in vivo tumour imaging tools
| Reagent | Targeta | Tumour-association | Reference |
|---|---|---|---|
| Nanobody | |||
| 8B6, 7C12, 7D12 | EGFR | Epidermoid and prostate | Huang et al. 2008; Gainkam et al. 2011; Oliveira et al. 2012; Kruwel et al. 2016 |
| 2Rs15d, 11A4 | HER-2 | Colon, breast and ovarian | Vaneycken et al. 2011; Xavier et al. 2013 |
| 1E2, 6E10 | HGF | Glioblastoma | Vosjan et al. 2012 |
| α-MMR | MMR | Mammary adenocarcinoma, Lewis lung carcinoma | Movahedi et al. 2012 |
| CEA1 | CEA | Colon | Vaneycken et al. 2010 |
| JVZ-007 | PSMA | Prostate | Chatalic et al. 2015 |
| DARPin | |||
| (HE)3-G3 | HER-2 | Colon, breast and ovarian | Mironova et al. 2014; Goldstein et al. 2015 |
| Monobody | |||
| E1 | hEphA2 | Lung, breast and colon | Park et al. 2015 |
| Anticalin | |||
| PRS-110 | HGFR | Various | Terwisscha van Scheltinga et al. 2014 |
| PRS-050 | VEGF-A | Various | Meier et al. 2014 |
| A3 | PSMA | Prostate | Barinka et al. 2016 |
| Affibody | |||
| ABY-025 | HER-2 | Colon, breast and ovarian | Sandberg et al. 2017 |
| affiFAP | EGFR | Epidermoid and prostate | Wang et al. 2017a |
| ZHPV16E7384 | HPV16 E6/E7 | Cervical | Xue et al. 2016 |
| CAIX | Renal | Garousi et al. 2016 | |
| 99mTc-ZIGFR:4551-GGGC | IGF-1R | Various | Mitran et al. 2015 |
| HEHEHE-z08698-NOTA | PDGFRβ | Various | Rosestedt et al. 2015 |
| Affimer | |||
| Anti-TNC Affimer | TNC | Various | Tiede et al. 2017 |
a EGFR epidermal growth factor receptor, HER-2 human epidermal growth factor receptor-2, HGF hepatocyte growth factor, MMR macrophage mannose receptor, CEA carcinoembryonic antigen, PSMA prostate specific membrane antigen, hEphA2 human eryhoropoietin-producing hepatocellular A2, HGFR hepatocyte growth factor receptor, VEGF-A vascular endothelial growth factor A, HPV16 E6/E7 human papillomavirus 16 E6 and E7 oncoproteins, CAIX carbonic anhydrase 9, IGF-1R insulin-like growth factor 1 receptor, PDGFRβ platelet-derived growth factor beta, TNC tenascin C