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. 2017 Aug 31;7:10240. doi: 10.1038/s41598-017-10717-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Disease-specific survival according to the PIK3CA mutation status in endometrial cancer. (a) PIK3CA mutation (exon9 and/or exon20) compared to no mutation detected. (b) PIK3CA exon9 mutations compared to PIK3CA exon20 mutations or non-mutated. (c) PIK3CA exon9 mutation leading to a change from negative to positive charge at affected amino acids (AA⁺), compared to mutation not leading to change of charge (AA°) and compared to no mutation. Curves are plotted by the Kaplan-Meier method; n = number of cases in each category followed by number of disease specific deaths, with comparison of survival between categories using log-rank (Mantel-Cox) test.