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. 2017 Aug 31;7:10152. doi: 10.1038/s41598-017-09232-y

Table 2.

DMS in PLIN1 in relation to obesity and age.

Probe Position Gene Relation to CpG Obesity status Age
region Island Never-obese Obese P 1 Std beta P 4
Explorative cohort
cg08749443 90224098 TSS1500 Open sea 0.114 ± 0.045 0.255 ± 0.113 1.1 × 10−4 −0.119 0.54
cg115264132 90223712 TSS1500 Open sea 0.122 ± 0.056 0.233 ± 0.100 2.7 × 10−4 −0.107 0.58
cg013487572 90223301 TSS1500 Open sea 0.244 ± 0.095 0.505 ± 0.142 1.1 × 10−4 0.046 0.81
cg01035422 90222555 5′UTR Open sea 0.181 ± 0.067 0.407 ± 0.122 2.5 × 10–5 −0.045 0.82
cg232056603 90212699 Body S_Shelf
cg20927724 90209326 Body S_Shore 0.200 ± 0.030 0.226 ± 0.047 0.012  0.044  0.92
cg04998447 90209223 Body Island 0.078 ± 0.018 0.117 ± 0.027 1.1 × 10−4 0.078 0.68
cg19571617 90209190 Body Island 0.038 ± 0.009 0.046 ± 0.015 0.16 −0.007 0.97
cg26703661 90208915 Body Island 0.064 ± 0.009 0.065 ± 0.021 0.62 0.08 0.68
cg05009389 90208810 3′UTR Island 0.041 ± 0.017 0.037 ± 0.008 0.68 0.052 0.79
cg265857243 90208739 3′UTR N_Shore
Validation cohort
cg08749443 90224098 TSS1500 Open sea 0.254 ± 0.105 0.331 ± 0.069 0.0008 0.318 0.0077
cg115264132 90223712 TSS1500 Open sea 0.268 ± 0.120 0.331 ± 0.084 0.0078 0.279 0.020
cg013487572 90223301 TSS1500 Open sea 0.421 ± 0.177 0.517 ± 0.091 0.004 0.384 0.0011
cg01035422 90222555 5′UTR Open sea 0.379 ± 0.135 0.483 ± 0.078 0.0004 0.332 0.0054
cg232056603 90212699 Body S_Shelf
cg20927724 90209326 Body S_Shore 0.212 ± 0.040 0.229 ± 0.032 0.066 0.380 0.0013
cg04998447 90209223 Body Island 0.089 ± 0.016 0.101 ± 0.018 0.021 0.364 0.0021
cg19571617 90209190 Body Island 0.053 ± 0.010 0.058 ± 0.009 0.014 0.112 0.359
cg26703661 90208915 Body Island 0.048 ± 0.012 0.044 ± 0.007 0.24 −0.017 0.89
cg05009389 90208810 3′UTR Island 0.035 ± 0.009 0.032 ± 0.006 0.15 −0.0074 0.95
cg265857243 90208739 3′UTR N_Shore

1Comparison of never-obese and obese group with Kruskal-Wallis test. Values are mean ± SD.

2SNP within 10 bps of interrogated CpG-site.

3SNP with MAF >10% in probes.

4Relationship between age and CpG-methylation was assessed by simple regression.