Figure 1.
Myogenic contractility is significantly different in Transition versus Peripheral zones of the human prostate. Representative traces of spontaneous activity in the (A) Transition Zone and (B) Peripheral Zone, and the average (C) resting basal tension, (D) amplitude, and (E) frequency of spontaneous contractions in the transition zone in comparison to the peripheral zone of matched patients (Student’s paired t-test, n = 10, * indicates p < 0.05, ** indicates p < 0.01). (F) representative images of I) & II) Azan Trichrome Staining and III) & IV) α-Smooth Muscle Actin (α-SMA) from the I) & III) Peripheral and II) & IV) Transition zone of a same matched patient. (G) Percent of positive stromal pixels corresponding to strong collagen staining in sections stained with Azan Trichrome (Student’s paired t-test. N = 4, **indicates p < 0.01) (H) Percentage of positive staining for α-SMA to the total stromal area (Student’s paired t-test. N = 4, **indicates p < 0.01).