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. 2017 Aug 31;7:10150. doi: 10.1038/s41598-017-07861-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Sildenafil (10⁻⁵ M) significantly decreases basal tension and frequency of myogenic contractility within the human prostate Transition Zone. (A) Basal tension, (B) amplitude, and (C) frequency of contractions pre and post sildenafil (10 µM) (Student’s paired t-test, n = 12, * indicates p < 0.05, ** indicates p < 0.01), (D) representative trace showing pre-treatment control activity and (E) representative trace showing treatment response. (F) Contractile Parameters following administration of sildenafil were converted to a percentage of the original (untreated) contractile parameters. Correlation between (G) age and percentage decrease of the frequency of spontaneous contractions (Linear Regression Analysis, p < 0.05 considered significant).