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. 2017 Aug 31;7:10229. doi: 10.1038/s41598-017-10323-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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SIRT6 is a potential target for osteoporosis treatment. (A) Micro CT and H&E analysis exhibited bone loss in OVX mice compared with sham mice. Scale bar for micro CT and H&E represents 1 mm and 20 µm, respectively. (B) OVX mice showed impaired trabecular number compared with sham mice. (C) OVX mice showed reduced bone volume compared with sham mice. (D) SIRT6 was decreased in bone sections from OVX mice compared with sham mice, as determined by histology and immunofluorescence staining. Scale bar represents 50 µm. (E) Quantification of normalized SIRT6 signals in (D). (F–H) Flow cytometry analysis of PDGFR- α⁺Sca-1⁺CD45⁻TER119⁻ cells. (I) Compared to sham mice, Sirt6 expression was dereased in primary MSCs from OVX mice, as determined by RT-qPCR. All data are shown as the mean ± SD, n = 3. **P < 0.01.