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. 2017 Aug 31;7:10269. doi: 10.1038/s41598-017-10108-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of RP105 deficiency on AVF maturation in vivo. (a) Quantification of morphometric parameters. Decrease in vessel circumference (outward remodeling) in RP105 deficient mice was observed 14 days after AVF creation, compared to WT. Lumen and intimal hyperplasia did not differ between RP105^−/− and WT mice. (b) Histological staining of venous outflow tract 14 days after surgery. Weigert elastine staining was used to determine histomorphometrical parameters of the vessel. Circumference (internal elastic lamina area) was used to quantify outward remodeling (red line). Intimal hyperplasia (green arrow) measured as a difference between luminal area (blue line) and vessel circumference. αSMA staining shows area of intimal hyperplasia 14 days after AVF creation. (#) intimal hyperplasia; P < 0.05; n = 11 per group. Bar = 200 μm; 100x magnification.