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. 2017 Aug 31;7:10269. doi: 10.1038/s41598-017-10108-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of RP105 deficiency on inflammatory response in vivo. Quantification and immunohistochemical staining of (a) MAC3⁺/CCR2⁺ macrophages and MAC3⁺/CD206⁺ macrophages (white arrows) and (b) CD3⁺ T-lymphocytes (black arrows) in AVF lesions 14 days after surgery. Decrease in cell number of pro-inflammatory macrophages and upregulation in anti-inflammatory macrophages upon RP105 deletion was observed. Bar = 100 μm. Number of CD3 T-lymphocytes was reduced in RP105 as compared to WT. Bar = 50 μm; 400x magnification. ^*P < 0.05; n = 11 per group.