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. 2017 Aug 31;7:10272. doi: 10.1038/s41598-017-09880-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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DHT inhibits antral follicle growth and induces ovarian and body weight changes in a PCOS rat model. (A) 21 days old female rats were randomly divided into two experimental groups (CTL and DHT) and subcutaneously implanted for 30 days with a capsule with continuous DHT release. Sham animals received an implant without DHT. Results are expressed as mean ± SEM of 15 rats (n = 3 replicates each with 5 rats per group). Data were analyzed by Student “t” test. Body weight: ***P < 0.001 (vs. CTL). Ovarian weight: ***P < 0.001 (vs. CTL). (B) Hematoxylin and eosin staining of CTL and DHT-treated ovaries. DHT-treated rat ovaries showed smaller ovarian size and contain lower numbers of antral follicles. Results are expressed as mean ± SEM of 15 ovary (n = 3 replicates each with 5 per group). Data were analyzed by two-way ANOVA and Bonferroni post hoc test. Preantral and early antral follicle (PAF) group: **P < 0.001 (vs. CTL). Antral follicle (AF) group: ***P < 0.001 (vs. CTL). Atypical follicle (Atypical F) group: ***P < 0.001 (vs. CTL). CL, corpus luteum; NO, not observed.