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. 2017 Aug 31;7:10103. doi: 10.1038/s41598-017-10311-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Involvement of hsa-miR-608 in gene regulation of CDC42 by dioxin. Cells were transfected with hsa-miR-608 inhibitors or NC for 24 hr, followed by 10⁻¹⁰ M TCDD treatment for an additional 36 hr. Total mRNAs was extracted for determination of the expression level of CDC42. Quantitative PCR analyses were performed as mentioned in M & M. 18 S rRNA was used as an internal control. Values are expressed as mean ± S.E. from triplicate samples in three independent experiments. Statistical analysis was done by one-way ANOVA with Bonferroni test. **p < 0.01 compared with Control (DMSO treated cells) & NC (NC transfected cells) group, ^##p < 0.01 compared with Control (DMSO treated cells) & hsa-miR-608 inhibitor (Inhibitor transfected cells) group, ^ααp < 0.01 compared with TCDD (TCDD treated cells) & NC (NC transfected cells) group.