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. 2017 Aug 31;7:10124. doi: 10.1038/s41598-017-10638-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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NOTCH2 participated in Jagged1 induced odonto/osteogenic differentiation by hDPs. The shNOTCH2 and shControl transduced hDPs were seeded on indirect immobilized Jagged1 or the hFc control surfaces and maintained in osteogenic medium for 3 and 7 days. The mRNA expression of Notch target genes and osteogenic related genes was determined using real-time polymerase chain reaction (A–F). ALP enzymatic activity was evaluated (G,H). Mineral deposition was stained with Alizarin Red S dye at day 14 (I,J). Bars indicate a significant difference between groups (p < 0.05). Black dot (•) indicates an outlier data point.